WEIGHT LOSS GUIDE

The GLP-1 receptor agonists like Semaglutide have taken the weight loss world by storm, offering a revolutionary approach to shedding pounds and improving overall health.

In this guide, we dive deep into GLP-1 receptor agonists, exploring their mechanism of action and how they can help you reach your weight loss goals. We'll also break down the differences between popular brands like Wegovy and Mounjaro,  And of course, we'll cover essential lifestyle considerations for optimizing your results, ensuring that you get the most out of your investment if you decide to move forward with using a GLP-1 for your health journey. 

 

If you're ready to take control of your health and see real results, GLP-1 receptor agonists may be just what you need. We will guide you through everything you need to know about these groundbreaking medications and how they can transform your life.

 

UNDERSTANDING GLP-1 MEDICATIONS

 

WHAT ARE THEY?

GLP-1 stands for Glucagon-Like Peptide. Glucagon is a naturally occurring hormone in the body. GLP-1 is a peptide that looks and acts very similar to glucagon, and that's why it's called "glucagon-like". 

 

These medications have been around for 20-plus years as a medication for type II diabetes. It's only recently have they become known for their ability to help with weight loss, regardless of a diabetes diagnosis.

 GLP-1 acts on the brain, particularly the hypothalamus, to reduce appetite and promote a feeling of satiety, which leads to decreased food intake.

GLP-1 receptor agonists help to regulate blood sugar levels and improve insulin sensitivity. At the same time, they slow gastric emptying, which can help prevent spikes in blood sugar after meals.

Additionally, these medications have been shown to reduce appetite and food intake, making it easier for individuals to make healthy eating choices and maintain a lower body weight.

HOW DO THEY WORK?

Semaglutide and other GLP-1 receptor agonists work by binding to the GLP-1 receptors in the pancreas, which stimulates the release of insulin while lowering glucagon secretion. This process helps lower blood glucose levels. Additionally, by slowing gastric emptying, they increase satiety, leading to reduced calorie intake.

Additional research has also revealed they reduce inflammation, which may improve chronic illnesses such as osteoarthritis, Parkinson's, and heart disease. 

LEPTIN RESISTANCE

Leptin is a hormone involved in regulating hunger signals. When leptin is released, it signals the brain that you're full. Leptin resistance is a condition where the body does not respond effectively to leptin signals, leading to increased food intake and weight gain. GLP-1 receptor agonists can indirectly improve leptin sensitivity by promoting weight loss and improving metabolic health.  

Metabolic Benefits:

• Improved Insulin Sensitivity: Weight loss induced by GLP-1 receptor agonists is often accompanied by improvements in insulin sensitivity and other markers of metabolic health.
• Reduction in Fat Mass: These medications particularly help reduce visceral fat, which is associated with a higher risk of metabolic diseases.
• Craving Reduction: GLP-1 receptor agonists may reduce cravings for high-fat and high-sugar foods, further aiding in weight management.
• Food Preferences: Patients on GLP-1 therapies often report changes in food preferences, favoring healthier options.

UTILIZING A GLP-1 FOR WEIGHT LOSS

When using a GLP-1 for weight loss, patients can expect gradual weight reduction, primarily due to decreased appetite and caloric intake. Initial results are typically seen within the first few weeks, with more significant weight loss occurring over months. To be more granular, Semaglutide research findings show:

 

1 out or 2 (50%) will lose 10-15% of body weight

1 out of 3 (33%) will lose 20% of body weight

4 out of 5 (80%) will lose at least 5% of body weight 

1 out 5 people may not respond at all

Clinical data show that in a 6-month period, the most common amount of weight loss is around 40 pounds or around 15% of total body weight. 

Here are five reasons why incorporating nutrition, supplements, and lifestyle is crucial for achieving and maintaining long-term success.

(1) Enhances Medication Efficacy: 

Nutrition and lifestyle changes can significantly enhance the efficacy of Semaglutide. A balanced diet that's low in processed foods and sugars and high in fiber, lean proteins, and healthy fats can improve insulin sensitivity and promote a more stable blood glucose level. This synergy between diet and medication can lead to more significant and sustainable weight loss and better glycemic control, making the treatment more effective overall.(2) Reduces Side Effects:

Adopting a healthy lifestyle can help mitigate some of the side effects associated with Semaglutide. For instance, gastrointestinal side effects like nausea and diarrhea, which are common when starting Semaglutide, can be alleviated by adjusting dietary habits—eating smaller, more frequent meals, and focusing on easily digestible foods. Hydration and certain supplements can also play a role in minimizing discomfort and enhancing the body's adaptation to the medication.

(3) Prevents Nutrient Deficiencies:

A comprehensive approach ensures nutritional needs are met. While focusing on weight loss, it's crucial to ensure the body receives all necessary nutrients to function optimally. Specific supplements, such as a high-quality multivitamin, omega-3 fatty acids, and fiber supplements, can support overall health, fill nutritional gaps in the diet, and aid in preventing deficiencies that could compromise health and hinder progress.

(4) Supports Mental and Emotional Well-being:

Mental and emotional health are vital components of successful weight management. Stress, anxiety, and depression can not only sabotage weight loss efforts but also lead to unhealthy eating patterns. Incorporating stress-reduction techniques, adequate sleep, regular physical activity, and possibly supplements like magnesium or omega-3 fatty acids can improve mental well-being. This holistic wellness approach supports the emotional resilience needed for long-term success.

(5) Ensures Sustainability and Prevents Rebound Weight Gain:

Long-term changes are key to preventing rebound weight gain. Semaglutide can effectively reduce appetite and promote weight loss, but without addressing the underlying habits that contribute to weight gain, the risk of rebounding once the medication is stopped remains high. Integrating healthy eating habits, regular physical activity, and a mindful approach to food can help establish a sustainable lifestyle that supports weight maintenance in the long run.

 

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What is Wegovy? (Available)

Wegovy is a weight loss medication that has been proven to work in clinical trials. It is made by Novo Nordisk and comes as a pre-filled pen that you can give yourself injections with, once a week.

It works by making you not want to eat as much. When used with a healthy diet and exercise, it can help you lose weight.

It’s available on prescription for people with a body mass index (BMI) of 30 and above, or 27 and above with weight-related conditions.

• Wegovy is injected under the skin once a week with or without food. You should try to take it at the same time each week. Each Wegovy pen has 4 doses and lasts for 4 weeks of treatment, then you'll need to start a new pen.

  Always double check you have the correct dose prescribed and that you have the right medication before injecting. This may seem obvious, but it’s always best to make sure.

  When choosing where to inject Wegovy, try to inject it in a different place each week. The best places to inject Wegovy are the stomach, upper legs, or upper arms.

  Taking your Wegovy injection

  Ensure you have read the Wegovy patient information leaflet for full instructions, diagrams and follow our additional doctor advice. The steps below are a general guide and do not replace this information.

  Check the name and dose of your Wegovy pen to ensure it matches your prescription request. Remove the pen cap and check the liquid is clear and colourless. Use a new needle for each weekly dose. Attach and secure the needle. Remove the outer and inner needle cap and perform a flow check of the pen as per the leaflet instructions (this only needs to be done when using the pen for the first time). Set the dose on your pen by turning the dose selector until the correct dose is showing. Select your skin injection site (e.g. thighs, abdomen). Insert the needle into the skin at a straight angle, as shown in the diagram in the patient information leaflet. You should be able to see the dose counter. Remove the needle and carefully replace the outer needle cap. Unscrew the needle and dispose of the two together in a sharps bin. If there are still doses left in your pen, place the pen cap back on, and safely store it for future use.

  Wegovy is best taken at the same time each week, so it’s important to set yourself a reminder, so you don’t forget.

  How much Wegovy do I take?

  The usual dose is 2.4mg, but your treatment will start at a lower dose and gradually increase.

  Wegovy dosage plan:

  weeks 1-4: 0.25mg once a week weeks 5-8: 0.5mg once a week

   

  You should never increase your dose after you reach the maximum dose of 2.4mg a week.

  • weeks 9-12: 1mg once a week
  • weeks 13-16: 1.7mg once a week
  • week 17 and onwards: 2.4mg once a week
  •  

  Who can take Wegovy?

  Wegovy can be taken for losing and maintaining a healthy weight in adults. To start Wegovy treatment your BMI must be 30 or over. Alternatively, you must have a BMI of 27 or over and a weight-related health problem such as diabetes.

  You should speak to your doctor before using Wegovy pens if you have:

  • kidney problems
  • diabetes
  • inflammation of your pancreas
  • low blood sugar levels (hypoglycaemia)
  • diabetic eye disease (retinopathy)

  You should not take Wegovy if you are allergic to any of the ingredients in the medication. Wegovy is not suitable for women who are pregnant or breastfeeding.

  What if I miss a dose of Wegovy?

  If you forget to take Wegovy and it has been 5 days or less since it was due, you can take Wegovy as soon as you remember. Take your next dose on your usual injection day, even if this means you are taking your next dose within 2 or 3 days.

  If you have missed a dose of Wegovy and it has been longer than 5 days since your dose was due, skip your missed dose. You can then continue your treatment when your next dose is due. Never take a double dose, as this can increase your risk of side effects.

  Very common side effects of Wegovy include:

  • headache
  • diarrhoea
  • constipation
  • nausea or vomiting (feeling or being sick)
  • feeling weak or tired
  • stomach pain

  These side effects go away over time and once your body gets used to the medication. You are given Wegovy gradually to reduce the risk and severity of these side effects.

  Common side effects of Wegovy include:

  • upset stomach or indigestion
  • dizziness
  • burping or gas (flatulence)
  • bloating
  • reflux or heartburn
  • hair loss
  • reactions at the injection site, such as redness, swelling, or soreness
  • gallstones
  • inflamed stomach (gastritis), which can cause nausea, vomiting, and stomach ache
  • hypoglycemia

  Uncommon side effects of Wegovy include:

  • fast heartbeat
  • an increase in pancreatic enzymes, which will show up in blood tests
  • delayed gastric emptying (gastroparesis)

  Wegovy also has some serious side effects, which should be treated straight away:

  • In diabetic patients, a common serious side effect is complications of diabetic eye disease (diabetic retinopathy). If you have diabetes you should inform your doctor if you experience eye problems, such as changes in vision, during treatment with this medicine.
  • An uncommon serious side effect is an inflamed pancreas (acute pancreatitis). If you have long lasting and severe pains in your stomach or back, speak to your doctor straight away or call 999.
  • A rare serious side effect of Wegovy is a severe allergic reaction. You must call 999 or get to A&E straight away if you have breathing problems, wheezing, difficulty swallowing, swelling in your face and throat, dizziness, or weakness.

  You can find out more about the side effects of Wegovy in your patient information leaflet.

  Interactions

  Wegovy can interact with other medications, so it’s important to tell your doctor what you’re currently taking before starting treatment. Your doctor may change the dose of your other medications whilst taking Wegovy to make sure it’s safe for you to take.

  Wegovy interacts with insulin and sulfonylureas, which are both treatments for type 2 diabetes. Taking Wegovy with one of these medications can increase the risk of low blood sugar levels.

  You should never use Wegovy with another medication that contains a GLP-1 receptor agonist, such as Saxenda.

  How long does nausea last with Wegovy?

  This is different for everyone. You may feel sick for a few days to a few weeks after starting Wegovy, and this side effect might come back when you increase your dose. Speak to your doctor if your nausea isn’t going away or is getting worse and interfering with your daily activities.

• Any Wegovy® pens that haven’t been opened should be kept in the fridge.
• During use you can keep the pens for 6 weeks in the fridge or room temperature (below 30°C).
• Pens need to be disposed of in the sharps bin you’re given when you start your treatment.
• When you're prescribed Wegovy® you’ll need to check your local council’s website to find out how to get rid of the sharps bin and its contents. 

 

Mounjaro( Tirzepatide) - Available

Mounjaro is a weekly self–injectable pen used for weight loss. It contains tirzepatide which works by regulating blood sugar and energy balance levels, helping to reduce appetite and prevent cravings.

Tirzepatide works on two different hormonal receptors: glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). You may have heard of GLP-1 from other weight loss injections.

GLP-1 helps to regulate blood sugar levels, which in turn talks to the brain to make you feel less hungry and prevent cravings. It also slows down the emptying of the stomach to keep you feeling fuller for longer.

GIP regulates energy balance in brain and fat cells, enhancing the GLP-1 effect of suppressing your appetite and improving sugar control.

By mimicking the effects of both these naturally occurring hormones, Mounjaro has been shown to have greater weight loss potential than medicines that work on GLP-1 alone.

You inject Mounjaro under the skin (subcutaneously) in your stomach area, thigh or upper arm once a week using an injection pen. Don’t worry, it’s actually much easier than it sounds and if we prescribe Mounjaro for you, we’ll provide you with full instructions on how to use it.

Usually, you’ll start with a dose of 2.5 mg of Mounjaro, which will increase every four weeks (or as advised and if suitable for you) until you reach your maximum maintenance dose of 5mg, 10mg or 15mg.

If you’re wondering how much weight you can lose on Mounjaro, clinical trials have shown that patients could achieve at least 20% weight loss after using tirzepatide for 72 weeks (18 months) when combined with healthy lifestyle changes.

Mounjaro can cause some side effects to occur. Very common ones are gastrointestinal in nature: nausea, vomiting, diarrhoea and constipation. These are mainly seen with dose increases, and tend to settle with time.

Other common side effects could include: fatigue, feeling lightheaded, excess wind (flatulence), gallstones, gastroesophageal reflux, injection site reactions, hair loss and hypoglycemia in patients with type 2 diabetes.

In rare cases, there can be serious side effects, such as:

Pancreatitis – if you develop severe abdominal pain, with or without persistent vomiting, this may be a sign of pancreatitis and you need to get medical help immediately.

Anaphylaxis – if you experience difficulty breathing, swelling of the face, lips or tongue and difficulty swallowing, you may be having a severe allergic reaction (anaphylaxis) and you must seek immediate medical help.

Please read the Patient Information Leaflet that comes with your medicine for full details of side effects and how to use Mounjaro.

Mounjaro is approved for people with a BMI over 30 (obesity), as well as those with a BMI over 27 (overweight) who also have weight-related health problems such as prediabetes, high blood pressure, high cholesterol, or heart problems.

You shouldn’t use tirzepatide if you’re pregnant, and you should stop taking Mounjaro at least one month before trying to get pregnant.

Mounjaro is not suitable in some medical circumstances, for example if you use some other diabetes medicines, have severe problems with digesting food, or have a history of pancreatitis or thyroid cancer. If you’re allergic to tirzepatide or any of the other ingredients in this weight loss injection treatment, you must not use Mounjaro.

It’s essential that you give us a full medical history and details of any conditions or other medicines you’re taking when you fill out our online questionnaire. This ensures we’re able to prescribe weight loss treatment that’s suitable and safe for you.

If you’re using Saxenda or Wegovy, you’ll need to wait 1 month before switching to Mounjaro. This is called the 'washout' period, and gives the body time for the first drug to leave the system. All patients using Mounjaro for the first time will start with 2.5mg. Keep in mind, Mounjaro may not be suitable for you (even if you're using another weight loss medicine). We’ll assess if it’s right for you during your consultation.

What happens if you miss a dose of Mounjaro®?

If you’ve missed a dose of Mounjaro® you should take the missed dose within 4 days after the missed dose. Try to take it as soon as possible after you’ve realised you’ve missed it.

If more than 4 days have passed since the missed dose, then skip it and take your next dose on your scheduled day. Make sure not to take 2 doses within 3 days of each other.

What is the best time to inject Mounjaro®?

You should inject Mounjaro® on the same day every week. You can take it at any time of day. You might want to set a reminder on your phone, so you don’t forget what day you normally take it.  

Wegovy and Mounjaro are both weekly injection pens and work in similar ways to aid weight loss. Mounjaro has proven more effective in clinical trials, as it works on GLP-1 and GIP hormones, whereas Wegovy only works on GLP-1.  Deciding if or which medicine is right for you will depend on different factors, which we’ll assess during your consultation. If you’re already on Wegovy  and losing weight, we recommend you keep using it. Keep in mind, weight plateaus are normal on your weight loss journey.
Prices :

First appointment  : £250 includes weight loss injecion supply for one month(Wegovy 0.25mg or Mounjaro 2.5mg)  , needles and yellow bin for sharps

Mounjaro 5mg - £220 , 7.5mg- £230 , 10mg -£230 (one month supply)

Wegovy - 0.5mg, 1mg - £200  for one month supply . 

Wegovy 1.7mg - £250 for one month supply.

Wegovy 2.4mg - £300 for one month supply.

 

 Extra tips

1. WEIGHT TRAINING IS A NON-NEGOTIABLE ADJUNCT TO GLP-1 TREATMENT

Weight training, often overlooked in weight loss, is a critical component of a comprehensive approach to using GLP-1 and maintaining success after its discontinuation. Here's why incorporating weight training is essential for those on GLP-1therapy and how it continues to provide benefits long after the medication is stopped.   

 

(1) Preservation of Muscle Mass Combats Muscle Loss:

GLP-1 medicines contributes to weight loss primarily through reduced appetite and caloric intake, which can lead to muscle mass loss alongside fat loss. Weight training is essential as it helps preserve and even build muscle mass during weight loss. Muscle is metabolically active tissue that consumes calories, even at rest, meaning its preservation or growth can help sustain a higher metabolic rate. 

(2) Enhanced Metabolic Rate Boosts Metabolism:

Regular weight training increases muscle mass, which in turn enhances your basal metabolic rate (BMR)—the number of calories your body burns at rest. An elevated BMR means your body is more efficient at using calories for energy throughout the day, reducing the likelihood of excess caloric intake being stored as fat. This metabolic boost is a key factor in ensuring that the weight lost with GLP-1 therapy is not regained once the medication is stopped.  

(3) Improved Insulin Sensitivity Increases Insulin Sensitivity:

Muscle contractions during weight training improve glucose uptake by muscle cells, enhancing insulin sensitivity. Improved insulin sensitivity means the body can better regulate blood sugar levels. This benefit of weight training works synergistically with GLP-1'S action, leading to more effective glycemic control and ultimately better quality of life!

(4) Reduction of Visceral Fat:

While GLP-1therapy aids in general weight loss, weight training specifically helps in reducing visceral fat—the dangerous fat surrounding your internal organs. High levels of visceral fat are associated with increased risks of heart disease, diabetes, and other metabolic conditions. Weight training, by improving body composition and reducing visceral fat, adds an extra layer of protection against these health issues.  

(5) Long-term Sustainability and Health Benefits Ensures Long-term Success:

The benefits of weight training extend far beyond the period of taking GLP-1 therapy. By building a routine that includes regular weight training, individuals are more likely to maintain their weight loss and continue improving their health after the medication is discontinued. Furthermore, weight training enhances strength, balance, and bone density, contributing to overall well-being and quality of life.

 Choose a trusted healthcare provider

In the UK, there have been reports of unregulated imports of weight loss injections and non-medically qualified practitioners. This weight management technique is only safe if carried out by a qualified and trained professionals like our pharmacists.

 Disclose your medical history

A trustworthy provider should always do a thorough check of your medical record and ask questions to determine if weight loss injections are a suitable and safe treatment path for you. You should disclose any current or previous medical conditions and medications that you have taken.